Objective To analyze the effect and safety of atorvastatin calcium tablets combined with drilling and drainage on inflammatory indexes in patients with chronic subdural hematoma (CSDH). Methods 74 cases of CSDH patients admitted to Wuxi Branch of Ruijin Hospital from February 2018 to February 2020 were selected, according to the random number table method, the patients were divided into control group (37 cases, treated with drilling and drainage) and observation group (37 cases, treated with drilling and drainage combined with atorvastatin calcium tablets). the clinical efficacy of the two groups was compared after 3 months of treatment; The changes of WHO quality of life assessment instrument (WHOQOL-BREF), KPS score and inflammatory factors before treatment and 3 months after treatment were compared between the two groups; The incidence of complications after 3 months of treatment was compared between the two groups. Results After 3 months of treatment, the total clinical effective rate of the observation group was higher than that of the control group; compared with before treatment, the KPS score and WHOQOL-BREF score of the two groups of patients increased after 3 months of treatment, and the observation group was higher than the control group; the levels of serum C-reactive protein (CRP) , interleukin-6 (IL-6) and interleukin-8 (IL-8) decreased, and the observation group was lower than the control group; during the treatment, the total incidence of complications in the observation group was lower than that in the control group (all P<0.05). Conclusion The combination of atorvastatin calcium treatment after drilling and drainage of CSDH patients can significantly improve the treatment effect, reduce inflammation, reduce the recurrence rate of hematoma, improve the patient's ability to take care of themselves, with high safety.