To investigate the effects of ivabradine combined with thrombus aspiration on the levels of cardiac function and plaque stability markers in patients with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI). Methods?A total of 130 AMI patients who received PCI treatment in The First Hospital of Qiqihar from April to October 2020 were divided into control group and experimental group according to random number table method, with 65 cases in each group. Patients in the control group were treated with conventional treatment regimens, and patients in the experimental group were treated with ivabradine combined with thrombus aspiration on the basis of the control group. Patients in both groups were treated for 8 weeks. The cardiac function of the two groups of patients before treatment and after 4 and 8 weeks of treatment, the levels of plaque stability markers, vascular endothelial function indexes and inflammatory factors were compared between the two groups of patients before and after treatment. Results?Compared with before treatment, after 4 and 8 weeks of treatment, the six-minute walk test (6MWT) distance of the two groups of patients extended, and the experimental group was longer than the control group; Compared with before treatment, the serum malondialdehyde (MDA) , Cardiac creatine kinase isoenzyme(CK-MB), vascular endothelin 1(ET-1), high-sensitivity C-reactive protein(hs-CRP), interleukin-6(IL-6) levels of the two groups of patients after treatment decreased, and the experimental group was lower than the control group; while the vascular endothelial diastolic function index(FMD) level of the two groups increased, and the experimental group was higher than the control group (all P