Objective To explore the effects of cough and asthma syrup combined with budesonide on lung function, serum C-reactive protein (CRP), procalcitonin (PCT), Neutrophil proportion (N%) levels in patients with chronic obstructive pulmonary disease (COPD). Methods 80 COPD patients admitted to Dazhou integrated TCM ＆ Western Medicine Hospital from October 2019 to October 2020 were selected as the research objects, according to the random number table method, they were divided into control group and treatment group, with 40 cases in each group. Patients in the control group were treated with budesonide aerosol on the basis of conventional treatment, patients in the treatment group were treated with cough and asthma syrup on the basis of the control group. Both groups of patients were treated continuously for 14 d. The clinical efficacy of the two groups of patients after treatment, the forced expiratory volume in the first second (FEV1), forced vital capacity (FVC), the proportion of forced expiratory volume in the first second to forced vital capacity (FEV1/FVC) and serum CRP, PCT, N% levelso were compared. Results After treatment, the total clinical effective rate of patients in the treatment group was 97.50%, which was higher than 80.00% in the control group; compared with before treatment, the FEV1, FVC, FEV1/FVC ratios of the two groups of patients increased after treatment, and the treatment group was higher than the control group; serum CRP, PCT, N% levels of the two groups of patients decreased, and the treatment group was lower than the control group (all P <0.05). Conclusions Cough and asthma syrup combined with budesonide treatment can significantly improve the lung function of patients with COPD, relieve their clinical symptoms, inhibit their inflammatory response, thereby control the development of the disease and improve the treatment effect.