Objective To study the effects of Trimetazidine combined with Rosuvastatin on cardiac function, blood lipid index and hemorheology index in patients with stable angina pectoris. Methods A total of 102 patients with table angina pectoris who were admitted to Hunan Provincial People's Hospital(The First Affiliated Hospital of Hunan Normal University) from February 2016 to February 2018 were divided into the control group (51 cases) and the observation group (51 cases)according to the random number table method. Patients in both groups received conventional treatment, patients in the control group were treated with Rosuvastatin on the basis of conventional treatment, while patients in the observation group were treated with Trimetazidine on the basis of the control group, both groups were treated for 1 month. The clinical efficacy after treatment, cardiac function index, blood lipid index and hemorheology index before and after treatment of patients were compared between the two groups. Results After treatment, the total clinical effective rate in the observation group was 88.24%, which was higher than that 70.59% in the control group; compared with before treatment, the levels of ejection fraction (EF), cardiac index (CI), cardiac output (CO), stroke volume (SV) and high density lipoprotein cholesterol (HDL-C) levels of patients in the two groups increased after treatment , and the observation group was higher than the control group; compared with before treatment, the levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), whole blood high shear viscosity, whole blood low shear viscosity and plasma viscosity of patients in the two groups decreased after treatment, and the observation group was lower than the control group (all P <0.05). Conclusion Trimetazidine combined with Rosuvastatin for the treatment of patients with stable angina pectoris can increase the clinical efficacy, improve cardiac function, regulate the levels of blood lipid and hemorheology index, and the treatment effect is more significant.