Objective To research the effects of Carprost ambutritol on postpartum hemorrhage and prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), fibrinogen (FIB) levels in high-risk cesarean section parturients. Methods A total of 1 000 cases high-risk cesarean parturients who were admitted to Fengshun County People's Hospital from January 2014 to December 2019 were divided into the control group and the observation group according to the random number table method, with 500 cases in each group. Parturients in both groups underwent cesarean section, parturients in the control group received Oxytocin injection after the foetus were delivered, and parturients in the observation group received Oxytocin injection and Carprost tromethamine after the foetus were delivered. Parturients in the both groups were observed for 7 days after delivery. The heart rate, diastolic blood pressure and systolic blood pressure of parturients before and 24 hours after medication, the blood loss 2 and 24 hours after delivery, the lochia duration, coagulation function and the occurrence of adverse reactions after delivery of parturients were compared between the two group. Results Compared with before medication, the heart rate of parturients decreased, the systolic blood pressure and diastolic blood pressure of parturients increased 24 hours after medication, but there was no significant difference between the two groups (all P > 0.05); compared with 2 hours after delivery, the bleeding volume of parturients in the two groups increased significantly 24 hours after delivery, and the observation group was significantly lower than the control group; the lochia duration of parturients in the observation group was significantly shorter than that in the control group; compared with the antenatal, the PT, APTT, and TT of parturients in the two groups shortened significantly 24 hours after delivery, and the observation group was significantly shorter than the control group; compared with the antenatal, the FIB of parturients in the two groups significantly decreased at 24 hours after delivery, and the observation group was significantly lower than the control group (all P <0.05); during treatment, there was no significant difference in the total incidence of adverse reactions between parturients in the two groups（P > 0.05). Conclusion Carprost tromethamine can effectively improve coagulation function, reduce the amount of postpartum hemorrhage of highrisk cesarean section parturients, and prevent the postpartum hemorrhage, at the same time, it can shorten the lochia duration and there is no significant effect on the vital signs of parturients without increasing the adverse effects, the safety is good.