Objective? To investigate the clinical effect of applying non-invasive echocardiographic output detection technology in the treatment of patients with septic shock. Methods A total of 120 patients with septic shock who were treated in the Dalian NO.3 People's Hospital from July 2017 to January 2019 were selected as the research objects, and they were divided into the control group (60 cases) and the observation group (60 cases) according to the random number table method. Patients in the control group were monitored for pulse-indicated continuous cardiac output (PICCO) within 2 hours of admission, and patients in the observation group were tested by the ultrasonic cardiac output monitor (USCOM), patients in both groups were managed by cluster resuscitation for 6 hours. Compared the blood lactic acid levels and lactic acid clearance rates of of patients in the two groups when they were admitted to the ICU and 6, 24, and 72 hours after admitted to the ICU; compared the hemodynamic parameter levels of patients in the observation group when they were admitted to the ICU and 6, 24, 72hours after admitted to the ICU; compared the primary endpoint datas of patients in the two groups [72 h Acute Physiological Function and Chronic Health Status Score System Ⅱ (APACHE Ⅱ ) score, mechanical ventilation time, vasoactive drug application time, ICU stay time,multiple organ dysfunction syndrome (MODS) the incidence and fatality rate]. Results Compared with the time when they were admitted to the ICU, the lactic acid values of patients in the two groups 6, 24, and 72 h after admitted to the ICU showed a significant downward trend, and the lactic acid level of patients in the observation group was significantly lower than that in the control group 72 h after admitted to the ICU; the lactic acid clearance rate of patients in the two groups 24 and 72 h increased significantly, and the lactic acid clearance rate of the observation group was significantly higher than that of the control group at each time point ; compared with when they were admitted to the ICU, the peripheral vascular resistance (SVR) of patients in the observation group increased gradually 6, 24, and 72 h after admitted to the ICU, and the stroke volume variation (SVV) of patients in the observation group 6, 24, and 72 h after admitted to the ICUwere significantly lower than when they were admitted to the ICU, and the level of SVV 72 h after admied to the ICU was significantly lower than 24 h after admitted to the ICU ; the 72 h APACHE Ⅱ score of patients in the observation group was significantly lower than that of the control group. Moreover, the time of mechanical ventilation, the time of using vasoactive drugs, and the time of admission to the ICU were significantly shorter than those of the control group (all P <0.05), but there was no significant difference in the incidence and mortality of MODS between the two groups (all P >0.05). Conclusion? As a non-invasive hemodynamic detection technology, USCOM can monitor the hemodynamic status of patients with septic shock in real time, shorten the time of mechanical ventilation, use time of vasoactive drugs and stay in ICU, and improve the clearance rate of lactic acid without increasing the risk of patient death, the clinical treatment effect is better