Objective To investigate the effects of nutritional support method on plasma protein, liver and kidney function, serum endotoxin and diamine oxidase levels of patients with abdominal infection after intestinal rupture repair. Methods 65 cases patients with abdominal infection after intestinal rupture repair admitted to People's Hospital of Baise from August 2018 to December 2020 were divided into the control group (32 cases, received enteral nutrition) and the experimental group (33 cases, received parenteral nutrition combined with enteral nutrition) according to the random number table method,patients in the two groups received continuous 5 d nutritional support treatment. The plasma protein, liver and kidney function indexes, serum endotoxin, diamine oxidase and gastrointestinal intolerance of patients in the two groups before and after treatment were compared. Results Compared with before treatment, the levels of total protein, prealbumin and albumin of patients in the two groups significantly increased after treatment, and those in the experimental group were significantly higher than those in the control group (all P < 0.05);the levels of serum creatinine, aspartate aminotransferase and cystatin C of patients in the two groups after treatment significantly decreased compared with before treatment (all P < 0.05), but there were no statistical significance in all indexes between the two groups (all P > 0.05); after treatment, the levels of serum diamine oxidase and endotoxin of patients in the two groups significantly decreased compared with before treatment, and the experimental group was significantly lower than the control group (all P < 0.05); there were no significant difference in the incidence of vomiting, nausea, stomach distension and gastric retention between the two groups (all P > 0.05). Conclusion Compared with enteral nutrition alone, enteral nutrition combined with parenteral nutrition can improve the nutritional status of patients with abdominal infection after intestinal rupture repair by increasing the plasma protein level, which is helpful to maintain the integrity of intestinal mucosal structure and function, and has little impact on liver and kidney function indexes, and which has good security