Objective To study the effects of applying Amiodarone and direct current cardioversion in patients with ventricular tachycardia on the maintenance of sinus rhythm and left ventricular function. Methods A retrospective analysis of the clinical data of 60 patients with ventricular tachycardia admitted to the Shunde Hospital of Southern Medical University(The First People's Hospital of Shunde) from January to August 2019, according to the treatment method, they were divided into the Propafenone group and the Amiodarone group, 30 cases in each group. Patients of the two groups were treated with Propafenone group and Amiodarone group before direct currentcardioversion. Patients in both groups were followed up for 3 months after treatment. The success rate of acute electrical cardioversion, the recurrence rate of ventricular tachycardia within 3 months, the time of cardioversion, the maintenance effect of sinus rhythm before and 3 months after treatment, the left ventricular function before and after treatment, and the occurrence of adverse reactions after treatment were compared between the two groups of patients. Results The cardioversion time of patients in the Amiodarone group was significantly shorter than that in the Propafenone group (P < 0.05), and there was no significant difference between the two groups of patients in the success rate of acute electrical cardioversion and the recurrence rate of ventricular tachycardia within 3 months (all P >0.05); compared with before treatment, the maximum P wave time limit and P wave dispersion of the two groups of patients significantly shortened 3 months after treatment, and the Amiodarone group was significantly shorter than that of the Propafenone group; compared with before treatment, the left ventricular ejection fraction of the two groups of patients significantly increased after treatment, and the Amiodarone group was significantly higher than that of the Propafenone group, and the left ventricular diameter of the two groups significantly reduced after treatment, and the Amiodarone group was significantly smaller than that of the Propafenone group; after treatment, the total incidence of adverse reactions in the Amiodarone group was significantly lower than that in the Propafenone group (all P < 0.05). Conclusion Compared with the use of Propafenone, the use of Amiodarone and direct current cardioversion can significantly shorten the cardioversion time, maximum P wave time limit and P wave dispersion in patients with ventricular tachycardia, improve sinus rhythm maintenance and left ventricular function, and has higher safety