Objective? To investigate the effect of enteral nutrition combined with concurrent radiotherapy and chemotherapy on the nutritional status, percentage of CD4+ , CD8+ , and CD4+ /CD8+ ratio of patients with locally advanced cervical cancer. Methods 62 patients with locally advanced cervical cancer admitted to The Second Affiliated Hospital of Xuzhou Medical University from March 2017 to March 2021 were divided into two groups according to the random number table method, with 31 cases in each group. Patients in the control group were given conventional nutritional guidance combined with concurrent radiotherapy and chemotherapy, and patients in the research group were treated combined with enteral nutrition therapy on the basis of the control group. 21 days was a treatment cycle, and both groups were treated for 2 cycles. The clinical efficacy and nutritional compliance rate after treatment of patients in the two groups, the levels of hemoglobin (Hb), albumin (ALB), prealbumin (PA), percentage of CD4+ , CD8+ and CD4+ /CD8+ ratio before and after treatment, as well as the occurrence of adverse reactions during treatment of patients in th two groups were compared. Results? The difference of the short-term efficacy after treatment and the incidence of adverse reactions of nausea, vomiting with International Evaluation System for ADRs of chemotherapeutic drugs for cancer ≥?Ⅲ grade of patients between the two groups had no statistical significance (all P >0.05); compared with before treatment, the levels of serum Hb, ALB, PA of patients in the two groups significantly decreased after treatment, and the research group was significantly lower than the control group; the nutritional compliance rate increased significantly, and the research group was significantly higher than the control group; compared with before treatment, the percentage of CD4+ and CD4+ /CD8+ ratio of patients in the research group increased significantly, while those indexes of patients in the control group decreased significantly, and the research group was significantly higher than the control group; the percentage of CD8+ of patients in the research group significantly decreased after treatment, while the percentage of CD8+ of patients in the control group significantly increased, and the research group was significantly lower than the control group; during the treatment period, the incidence of adverse reactions of myelosuppression, abdominal pain and diarrhea with International Evaluation System for ADRs of chemotherapeutic drugs for cancer ≥?Ⅲ grade in the research group were significantly lower than those in the control group (all P <0.05). Conclusion? Enteral nutrition combined with concurrent radiation and chemoradiotherapy in the treatment of locally advanced cervical cancer can effectively improve the clinical therapeutic effect, improve the nutritional status of patients, regulate the immune function, improve the tolerance of treatment, and reduce the occurrence of adverse reactions