Objective To observe the curative effect of peripheral vascular stent intervention in the treatment of diabetic lower extremity arteriosclerosis obliterans complicated with foot gangrene and its effect on blood flow volume, inner diameter of blood vessels and levels of inflammatory factors, so as to provide a basis for improving clinical treatment effect and prognosis. Methods The clinical datas of 143 patients with diabetic lower extremity arteriosclerosis obliterans complicated with foot gangrene who were admitted to Maoming People's Hospital from December 2018 to December 2020 were retrospectively analyzed, and they were divided into the control group (70 cases) and the observation group (73 cases) according to the treatment method. The patients in the control group were treated with conventional treatments, such as hypoglycemic, antiplatelet, and anticoagulation, and underwent surgical debridement; the patients in the observation group were treated with peripheral vascular stent intervention on the basis of the control group, and the curative effect of patients in the two groups were evaluated 2 months after treatment. The total clinical effective rate, Wagner grade of diabetic foot, blood flow volum and inner diameter of iliac artery, superficial femoral artery and dorsal foot artery before and after treatment, as well as serum interleukin-6 (IL-6), C- reactive protein (CRP), tumor necrosis factor-α (TNF-α) levels before and after treatment of patients were compared between the two groups. Results After treatment, the clinical total effective rate and the proportion of patients with diabetic foot Wagner grade 0 and 1 in the observation group were significantly higher than those in the control group, and the proportion of patients with diabetic foot Wagner grade 2 and 3 were significantly lower than those in the control group (all P <0.05), and there was no significant difference in the proportion of patients with diabetic foot Wagner grade 4 between the two groups (P >0.05). After treatment, the vascular inner diameter and blood flow volume of iliac artery, superficial femoral artery and dorsal foot artery of patients in the observation group were higher than those in the control group; and the serum IL-6, CRP and TNF-α levels of patients in the two groups decreased significantly, and the observation group was significantly lower than thecontrol group (all P <0.05). Conclusion Peripheral vascular stent intervention in the treatment of diabetic lower extremity arteriosclerosis obliterans complicated with foot gangrene can effectively improve the clinical symptoms of patients, increase the vascular inner diameter and blood flow volume of the lower extremity arteries, and relieve the patients' inflammatory response effectively, the curative effect is definite