Objective To explore the clinical efficacy of desloratadine citrate combined with endoscopic sinus surgery on nasal mucociliary clearance function, allergic reaction and inflammatory factor levels in the treatment of chronic sinusitis. Methods A total of 100 patientswith chronic sinusitis admitted to Beijing Yanhua Hospital from March 2020 to March 2021 were selected as the research subjects, according to the random number table method, they were divided into control group and observation group, with 50 cases in each group. The patients in the control group were given endoscopic sinus surgery, on the basis of the control group, the patients in the observation group were treated with desloratadine citrate 1 month before the surgery. Both groups were followed up for 3 months after treatment. The clinical efficacy, visual analogue scale (VAS) of subjective symptoms, nasal mucociliary clearance function, serum total immunoglobulin E (TIgE), eosinophil cationic protein (ECP) and inflammatory factor levels before and after treatment were compared between the two groups. Results After treatment, the total clinical effective rate of patients in the observation group was 94.00%, which was significantly higher than 80.00% in the control group; compared with before treatment, the mucociliary clearance speed of the two groups of patients significantly increased after treatment, and the observation group was higher than the control group; the saccharin clearance time significantly shortened in both groups, and the observation group was shorter than the control group; the VAS of various symptoms, serum ECP, TIgE, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and interleukin-8 (IL-8) levels in the two groups significantly decreased, and the observation group was lower than the control group (all P<0.05). Conclusion Desloratadine Citrate combined with endoscopic sinus surgery in the treatment of chronic sinusitis can effectively relieve the clinical symptoms of patients, improve allergic reactions, reduce the body's inflammatory response, and the curative effect is significant.