Objective To observe the effect of different doses of gamma globulin combined with Aspirin on the clinical efficacy and immune function of children with Kawasaki disease, provide an effective reference for clinical treatment of the disease. Methods According to the random number table method, 66 children with Kawasaki disease who were admitted to the Yunyang District Maternal and Child Health Hospital from January 2020 to January 2021 were divided into the control group and the study group, with 33 in each group. The children inthe control group were treated with Aspirin and low-dose gamma globulin (1 g/kg body mass, once a day), and the children in the study group were treated with Aspirin and high-dose gamma globulin (2 g/kg body mass, once a day), the clinical efficacy of patients in the two groups were evaluated 8 weeks after treatment. The clinical efficacy and clinical symptom subsidence time were compared between the two groups after treatment, peripheral blood CD4+ , CD8+ percentage, CD4+ /CD8+ ratio, platelet count (PLT), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) levels before and after treatment, and adverse reactions during treatment were compared between the two groups. Results After treatment, the clinical total effective rate of the children in the study group was significantly higher than that in the control group; the extinction time of fever, swelling of hands and feet, mucosal congestion, cervical lymphadenopathy and skin rash of the study groups of children after treatment were significantly shorter than those of the control group; compared with before treatment, peripheral blood CD4+ , CD8+ percentage, CD4+ /CD8+ ratio in the two groups after treatment, and levels of PLT, ESR and CRP in the two groups significantly decreased, and the study group were significantly lower than the control group (all P<0.05). There were no significant difference in the total incidence of adverse reactions between the two groups during treatment (P>0.05). Conclusion High-dose gamma globulin combined with Aspirin in the treatment of Kawasaki disease can effectively improve the clinical treatment effect of children, regulate immune function, reduce the body's erythrocyte sedimentation rate and inflammatory response, and promote the body's recovery, and there are no serious adverse reactions, and the treatment safety is high.