Objective? To explore the effect of radial shock wave on hemodynamics and inflammatory response in the treatment of patients with narrow radial styloid tenosynovitis. Methods? A total of 90 cases patients with narrow radial styloid tenosynovitis addimitted in The First Hospital of Kunming from March 2020 to March 2022 were divided into the control group (45 cases, treated with diclofenac diethylamine emulsion) and the study group (45 cases, treated with radial shock wave) by the random number table method, patients in both groups were treated for 4 weeks. The hemodynamics, inflammatory factor level, pain degree, joint function before and after treatment, and the occurrence of adverse reactions during the treatment were compared between the two groups. Results? Compared with before treatment, after treatment, the visual analog pain scale (VAS) scores of patients in both groups significantly decreased, and the study group was significantly lower than thecontrol group; Cooney wrist function scores of patients in both groups significantly increased, and the study group was significantly higher than the control group; peak systolic velocity (PSV) and end diastolic velocity (EDV) of proper palmar digital artery of ring finger of patients in both groups increased significantly, and the study group was significantly higher than the control group; the resistance index (RI) and pulsatility index (PI) in both groups decreased significantly, and the study group was significantly lower than the control group; the serum C-reactive protein (CRP) and tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) levels of patients in both groups decreased significantly, and the study group was significantly lower than the control group(allP<0.05); there was no significant difference in the total incidence of adverse reactions between the two groups (allP>0.05). Conclusion? Narrow radial styloid tenosynovitis treated with radial shock wave can significantly improve the wrist function of patients, and can effectively relieve pain, at the same time, it can improve the Hemodynamics level of patients, inhibit inflammatory reaction, and has good safety.