Objective? To explore the application effects of massage combined with acupuncture in cervical spondylotic radiculopathy and its influence on the cervical spine mobility. Methods? A total of 80 patients with cervical spondylotic radiculopathy admitted to Dongguan Traditional Chinese Medicine Hospital from January to December 2020 were divided into the control group (40 cases, treated with acupuncture) and the experimental group (40 cases, combined with massage therapy on the basis of the control group) according to the random number table method. Patients in the two groups were received 4 consecutive courses of treatment. The clinical efficacy after treatment , and the neck disability index (NDI) score, visual analogue scale (VAS) score, cervical intervertebral disc height, and cervical spine range of motion (forward flexion, backward extension, left flexion, right flexion, left rotation, right rotation) and cervical spine function recovery time was compared between the two groups. Results? The total clinical effective rate of patients in the experimental group was higher than that in the control group; the NDI, VAS scores and serum lipid hydroperoxide (LPO) levels after treatment in the two groups were lower than those before treatment, and the experimental group was lower than the control group; the height of the intervertebral disc in the two groups decreased compared with that before treatment, and the experimental group was smaller than the control group; serum superoxide dismutase (SOD) levels in both groups were higher than those before treatment, and the experimental group was higher than the control group; the cervical spine flexion, extension, left flexion, right flexion, left rotation, and right rotation of the two groups of patients all increased compared with those before treatment, and the experimental group was larger than the control group; the recovery time of cervical spine function in the experimental group was shorter than that in the control group (all P<0.05). Conclusion? Massage combined with acupuncture therapy is effective in the treatment of cervical spondylotic radiculopathy.It can effectively reduce pain and oxidative stress state of the body, improve the mobility of the cervical spine, and promote the recovery of cervical spine function as soon as possible.