Objective To explore controlling nutritional status (CONUT) score on the predictive value for prognosis of patients with prostate cancer after androgen deprivation therapy, and provide reference for the clinical prediction of treatment effect. Methods The clinicaldata of 98 patients with prostate cancer who treated with androgen deprivation in Nantong Tumor Hospital from February 2018 to March 2020 were retrospectively analyzed, they were all followed-up for 2 years, and were divided into the CONUT score ≥?3 group (53 cases) and the CONUT score < 3 group (45 cases) according to the patients' CONUT score. The differences of general data between the two groups, the survival rates of patients with prostate cancer with different CONUT scores, the single factors affecting the prognosis of patients with prostate cancer after androgen deprivation therapy were analyzed, and the multivariate Cox regression analysis for the factors with statistically significant differences was conducted to screen out the independent risk factors affecting the prognosis of patients with prostate cancer after androgen deprivation therapy. Results The proportion of patients with TNM stage Ⅲ ~ Ⅳ , Gleason score > 7, lymph node metastasis and positive tumor resection margin in the CONUT score ≥3 group were significantly higher than those in the CONUT score < 3 group; after 2 years of follow-up, 66 patients (67.35%) survived, the survival rate was 54.72% (29/53) in the CONUT score ≥?3 group, and the survival rate was 82.22% (37/45) in the CONUT score < 3 group, the 2-year survival rate of patients in CONUT score < 3 group was significantly higher than that in CONUT score ≥3 group (all P<0.05); TNM stage, Gleason score, lymph node metastasis, CONUT score and positive tumor resection margin were risk factors for the prognosis of patients with prostate cancer after androgen deprivation therapy (HR=2.237, 2.309, 2.125, 2.784, 1.958, all P<0.05); multivariate Cox regression analysis showed that TNM stage Ⅲ ~ Ⅳ , CONUT score ≥3, Gleason score > 7 were independent risk factors for the prognosis of patients with prostate cancer after androgen deprivation therapy (HR =1.917, 3.370, 2.020, all P<0.05). Conclusion CONUT score is closely related to the prognosis of patients with prostate cancer after androgen deprivation therapy, and which has important guiding value for predicting the prognosis of patients with prostate cancer after androgen deprivation therapy. the CONUT score ≥?3 indicates that patients have a risk of poor prognosis.