Objective To analyze the effects of lumbar cistern catheterization combined with lateral ventricle drainage on the cerebral CT perfusion imaging parameters (mean transit time, time to peak contrast agent, cerebral blood flow, cerebral blood volume) in patients with ventricular hemorrhage, so as to provide reference for clinical treatment. Methods A total of 100 patients with intraventricular hemorrhage admitted to Urumqi Friendship Hospital from May 2020 to May 2022 were selected and divided into control group (50 cases, treated with traditional lateral ventricle drainage) and the experimental group (50 cases, treated with lumbar cistern catheterization combined with lateral ventricle drainage) according to the random number table method, both groups were followed up for 6 months after operation. The clinical curative effect, the total drainage time, ventricular hemorrhage disappear time, the clearing time of cerebrospinal fluid, mean transit time, time to peak contrast agent, cerebral blood flow, cerebral blood volume on the 3, 7, 14 days after operation, 36-item short form survey (SF-36) score before operation and 6 months after operation, and glasgow outcome scale (GOS) score 6 months after operation were compared between the two groups. Results The total clinical effective rate of patients in the experimental group after treatment was 96.00%, which was significantly higher than 82.00% in the control group; the total drainage time, ventricular hemorrhage disappear time, and the clearing time of cerebrospinal fluid in the experimental group were significantly shorter than those in the control group; compared with 3 days after operation, the mean transit time, time to peak contrast agent of patients in the two groups at 7 and 14 days after operation showed a trend of prolonging and then shortening, the experimental group was significantly shorter than the control group; cerebral blood flow, cerebral blood volume in the two groups decreased and then increased, the experimental group was significantly higher than the control group; compared with before operation, the scores of social function, mental health, emotional function and physiological function of patients in the two groups significantly increased at 6months after operation, the experimental group was significantly higher than the control group; the proportion of patients who recovered well (GOS score was 5 ) in the experimental group at 6 months after operation was significantly higher than that in the control group (all P<0.05). Conclusion Lumbar cistern catheterization combined with lateral ventricular drainage can shorten the drainage and ventricular hemorrhage time in patients with ventricular hemorrhage, promote prognosis recovery, improve the quality of life, with remarkable effect.